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Hokkaido University Collection of Scholarly and Academic Papers >
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Photoactive ligands probing the sweet taste receptor. Design and synthesis of highly potent diazirinyl D-phenylalanine derivatives
| Title: | Photoactive ligands probing the sweet taste receptor. Design and synthesis of highly potent diazirinyl D-phenylalanine derivatives |
| Authors: | Masuda, Katsuyoshi Browse this author | | Koizumi, Ayako Browse this author | | Misaka, Takumi Browse this author | | Hatanaka, Yasumaru Browse this author | | Abe, Keiko Browse this author | | Tanaka, Takaharu Browse this author | | Ishiguro, Masaji Browse this author | | Hashimoto, Makoto Browse this author |
| Keywords: | Sweet taste | | D-Amino acid | | Photoaffinity label | | Diazirine |
| Issue Date: | 1-Feb-2010 |
| Publisher: | Elsevier |
| Journal Title: | Bioorganic & Medicinal Chemistry Letters |
| Volume: | 20 |
| Issue: | 3 |
| Start Page: | 1081 |
| End Page: | 1083 |
| Publisher DOI: | 10.1016/j.bmcl.2009.12.029 |
| Abstract: | Some D-Amino acids such as D-tryptophan and D-phenylalanine are well known as naturally-occurring sweeteners. Photoreactive D-phenylalanine derivatives containing trifluoromethyldiazirinyl moiety at 3- or 4-position of phenylalanine, were designed as sweeteners for functional analysis with photoaffinity labeling. The trifluoromethyldiazirinyl D-phenylalanine derivatives were prepared effectively with chemo-enzymatic methods using L-amino acid oxidase and were found to have potent activity toward the human sweet taste receptor. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/42636 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 橋本 誠
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