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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Health Sciences / Faculty of Health Sciences >
Peer-reviewed Journal Articles, etc >
Possible implication of disordered neutrophil extracellular traps in the pathogenesis of MPO-ANCA-associated vasculitis
| Title: | Possible implication of disordered neutrophil extracellular traps in the pathogenesis of MPO-ANCA-associated vasculitis |
| Authors: | Nakazawa, Daigo Browse this author | | Tomaru, Utano Browse this author →KAKEN DB | | Ishizu, Akihiro Browse this author →KAKEN DB |
| Keywords: | NETs | | PTU | | MPO-ANCA | | MPO-AAV |
| Issue Date: | Oct-2013 |
| Publisher: | Springer |
| Journal Title: | Clinical and Experimental Nephrology |
| Volume: | 17 |
| Issue: | 5 |
| Start Page: | 631 |
| End Page: | 633 |
| Publisher DOI: | 10.1007/s10157-012-0738-8 |
| PMID: | 23224024 |
| Abstract: | Neutrophil extracellular traps (NETs) are characterized by the presence of extracellular DNA fibers studded with antimicrobial proteins, including myeloperoxidase (MPO). Although NETs play an important role in the innate immune system, the scattered extracellular enzymes, such as MPO, pose risks to the host. Therefore, NETs are strictly regulated by DNase I in the serum, which prevents them from persisting. Recent studies have demonstrated that dysregulation of NETs could be involved in the pathogenesis of autoimmune diseases, including systemic lupus erythematosus. In this review, we interpret the association of disordered NETs with autoimmune diseases, especially propylthiouracil-induced MPO-ANCA-associated vasculitis. |
| Rights: | The final publication is available at www.springerlink.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/54623 |
| Appears in Collections: | 保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 石津 明洋
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