| Title: | Bone Marrow Graft-versus-Host Disease : Evaluation of Its Clinical Impact on Disrupted Hematopoiesis after Allogeneic Hematopoietic Stem Cell Transplantation |
| Authors: | Shono, Yusuke Browse this author |
| Shiratori, Souichi Browse this author |
| Kosugi-Kanaya, Mizuha Browse this author |
| Ueha, Satoshi Browse this author |
| Sugita, Junichi Browse this author |
| Shigematsu, Akio Browse this author |
| Kondo, Takeshi Browse this author →KAKEN DB |
| Hashimoto, Daigo Browse this author |
| Fujimoto, Katsuya Browse this author |
| Endo, Tomoyuki Browse this author |
| Nishio, Mitsufumi Browse this author →KAKEN DB |
| Hashino, Satoshi Browse this author →KAKEN DB |
| Matsuno, Yoshihiro Browse this author |
| Matsushima, Kouji Browse this author |
| Tanaka, Junji Browse this author →KAKEN DB |
| Imamura, Masahiro Browse this author →KAKEN DB |
| Teshima, Takanori Browse this author →KAKEN DB |
| Keywords: | Bone marrow graft-versus-host disease (BM GVHD) |
| Idiopathic cytopenias |
| Osteoblasts |
| Issue Date: | Apr-2014 |
| Publisher: | Elsevier |
| Journal Title: | Biology of Blood and Marrow Transplantation |
| Volume: | 20 |
| Issue: | 4 |
| Start Page: | 495 |
| End Page: | 500 |
| Publisher DOI: | 10.1016/j.bbmt.2013.12.568 |
| PMID: | 24374213 |
| Abstract: | Idiopathic cytopenias are frequently observed in patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT). We have previously reported the effect of graft-versus-host disease (GVHD) on bone marrow (BM) in murine models, indicating that the osteoblast injury mediated by donor T cells was associated with bone marrow suppression and delayed immune reconstitution. In this study, we prospectively evaluated the relevance of these findings in 51 patients. Patients with chronic GVHD manifested the loss of osteoblasts, contributing to cytopenic symptoms (P =.0427 compared with patients without cytopenic symptoms). The loss of osteoblasts was significantly associated with the extensive type of chronic GVHD (P =.012), and flow cytometric analyses revealed lower numbers of CD19(+) B cells and a significantly increased CD4 to CD8 ratio (P.0002) in these patients. Our data, for the first time to our knowledge, summarize the detailed analyses of the effect of GVHD on BM in the clinical allo-HSCT patients. (c) 2014 American Society for Blood and Marrow Transplantation. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/55428 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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