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Orthopoxvirus infection among wildlife in Zambia
| Title: | Orthopoxvirus infection among wildlife in Zambia |
| Authors: | Orba, Yasuko Browse this author →KAKEN DB | | Sasaki, Michihito Browse this author →KAKEN DB | | Yamaguchi, Hiroki Browse this author | | Ishii, Akihiro Browse this author →KAKEN DB | | Thomas, Yuka Browse this author | | Ogawa, Hirohito Browse this author | | Hang'ombe, Bernard M. Browse this author | | Mweene, Aaron S. Browse this author | | Morikawa, Shigeru Browse this author →KAKEN DB | | Saijo, Masayuki Browse this author →KAKEN DB | | Sawa, Hirofumi Browse this author →KAKEN DB |
| Issue Date: | Feb-2015 |
| Publisher: | Society for General Microbiology |
| Journal Title: | Journal of General Virology |
| Volume: | 96 |
| Issue: | 2 |
| Start Page: | 390 |
| End Page: | 394 |
| Publisher DOI: | 10.1099/vir.0.070219-0 |
| PMID: | 25319753 |
| Abstract: | Human monkeypox is a viral zoonosis caused by monkeypox virus, an orthopoxvirus (OPXV). The majority of human monkeypox cases have been reported in moist forested regions in West and Central Africa, particularly in the Democratic Republic of the Congo (DRC). In this study we investigated zoonotic OPXV infection among wild animals in Zambia, which shares a border with DRC, to assess the geographical distribution of OPXV. We screened for OPXV antibodies in sera from non-human primates (NHPs), rodents and shrews by ELISA, and performed real-time PCR to detect OPXV DNA in spleen samples. Serological analysis indicated that 38 of 259 (14.7 %) rodents, 14 of 42 (33.3%) shrews and 4 of 188 (2.1 %) NHPs had antibodies against OPXV. The OPXV DNA could not be detected in spleens from any animals tested. Our results indicated that wild animals living in rural human habitation areas of Zambia have been infected with OPXV. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/60631 |
| Appears in Collections: | 人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 大場 靖子
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