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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Comparison of Different Symptom Assessment Scales for Multiple System Atrophy
| Title: | Comparison of Different Symptom Assessment Scales for Multiple System Atrophy |
| Authors: | Matsushima, Masaaki Browse this author →ORCID | | Yabe, Ichiro Browse this author →KAKEN DB | | Oba, Koji Browse this author →KAKEN DB | | Sakushima, Ken Browse this author | | Mito, Yasunori Browse this author | | Takei, Asako Browse this author | | Houzen, Hideki Browse this author | | Tsuzaka, Kazufumi Browse this author | | Yoshida, Kazuto Browse this author | | Maruo, Yasunori Browse this author | | Sasaki, Hidenao Browse this author →KAKEN DB |
| Keywords: | Multiple system atrophy | | Standardized response mean | | Symptom assessment scale | | Short-term change | | Sample size |
| Issue Date: | Apr-2016 |
| Publisher: | Springer |
| Journal Title: | The Cerebellum |
| Volume: | 15 |
| Issue: | 2 |
| Start Page: | 190 |
| End Page: | 200 |
| Publisher DOI: | 10.1007/s12311-015-0686-4 |
| PMID: | 26093615 |
| Abstract: | To identify the most sensitive scale for use in clinical trials on multiple system atrophy (MSA), a short and sensitive scale is needed for MSA clinical trials. Potential candidates are the Unified MSA Rating Scale (UMSARS), Scale for the Assessment and Rating of Ataxia (SARA), Berg Balance Scale (BBS), MSA Health-Related Quality of Life scale (MSA-QoL), and Scales for Outcomes in Parkinson's Disease-Autonomic questionnaire (SCOPA-AUT). We enrolled patients with MSA from eight hospitals in Hokkaido, Japan. Board-certified neurologists assessed each patient at 6-month intervals and scored them on the UMSARS, SARA, BBS, MSA-QoL, and SCOPA-AUT. Score changes were evaluated using the standardized response mean (SRM). The correlation between disease duration and each score was examined. The first evaluation was conducted on 85 patients (60 patients with MSA cerebellar ataxia dominant subtype [MSA-C] and 25 patients with MSA Parkinsonism-dominant subtype [MSA-P]). Sixty-nine patients were examined after 6 months and 63 patients after 12 months. The UMSARS Part 4 had the largest SRM after 6 months and the SARA after 12 months. SRMs for MSA-P, the shorter duration group, and the early-onset group were larger than were those for MSA-C, the longer duration group, and the late-onset group. SRMs for items regarding skilled hand activities, walking, and standing were relatively large. Our study indicates that the UMSARS (parts 2 and 4), SARA, and BBS are sensitive scales for evaluating MSA progression over 12 months. Items with large SRMs effectively evaluated short-term changes. |
| Rights: | The final publication is available at link.springer.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/64957 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松島 理明
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