|
Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Science / Faculty of Science >
Peer-reviewed Journal Articles, etc >
Identification of novel sesterterpenes by genome mining of phytopathogenic fungi Phoma and Colletotrichum sp.
This item is licensed under:Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
| Title: | Identification of novel sesterterpenes by genome mining of phytopathogenic fungi Phoma and Colletotrichum sp. |
| Authors: | Gao, Lei Browse this author | | Narita, Koji Browse this author | | Ozaki, Taro Browse this author | | Kumakura, Naoyoshi Browse this author | | Gan, Pamela Browse this author | | Minami, Atsushi Browse this author →KAKEN DB | | Liu, Chengwei Browse this author | | Lei, Xiaoguang Browse this author | | Shirasu, Ken Browse this author | | Oikawa, Hideaki Browse this author →KAKEN DB |
| Keywords: | Sesterterpene synthase | | Genome mining | | Natural product biosynthesis | | Phytopathogen | | Heterologous expression |
| Issue Date: | 21-Mar-2018 |
| Publisher: | Elsevier |
| Journal Title: | Tetrahedron Letters |
| Volume: | 59 |
| Issue: | 12 |
| Start Page: | 1136 |
| End Page: | 1139 |
| Publisher DOI: | 10.1016/j.tetlet.2018.02.022 |
| Abstract: | Two homologous gene clusters for the biosynthesis of sesterterpenes betaestacins were identified from two phytopathogens, Phoma betae and Colletotrichum orbiculare. Heterologous expression of identified oxidation enzymes with previously-characterized PbTS1 (BtcA(pb)) resulted in the production of seven novel sesterterpenes. Although both strains possessed homologous enzymes, oxidation state of corresponding products were different from each other, suggesting that structural diversification of sesterterpene skeletons might be achieved by these homologous enzymes with different functions. (C) 2013 Elsevier Ltd. All rights reserved. |
| Rights: | ©2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license | | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/76980 |
| Appears in Collections: | 理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 及川 英秋
|
