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Oral Supplementation of the Vitamin D Metabolite 25(OH)D(3)Against Influenza Virus Infection in Mice
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| Title: | Oral Supplementation of the Vitamin D Metabolite 25(OH)D(3)Against Influenza Virus Infection in Mice |
| Authors: | Hayashi, Hirotaka Browse this author | | Okamatsu, Masatoshi Browse this author | | Ogasawara, Honami Browse this author | | Tsugawa, Naoko Browse this author | | Isoda, Norikazu Browse this author | | Matsuno, Keita Browse this author | | Sakoda, Yoshihiro Browse this author →KAKEN DB |
| Keywords: | vitamin D | | 25-hydroxyvitamin D-3 | | cytokines | | influenza |
| Issue Date: | Jul-2020 |
| Publisher: | MDPI |
| Journal Title: | Nutrients |
| Volume: | 12 |
| Issue: | 7 |
| Start Page: | 2000 |
| Publisher DOI: | 10.3390/nu12072000 |
| Abstract: | Vitamin D is a fat-soluble vitamin that is metabolized by the liver into 25-hydroxyvitamin D [25(OH)D] and then by the kidney into 1,25-dihydroxyvitamin D [1,25(OH)(2)D], which activates the vitamin D receptor expressed in various cells, including immune cells, for an overall immunostimulatory effect. Here, to investigate whether oral supplementation of 25-hydroxyvitamin D-3[25(OH)D-3], a major form of vitamin D metabolite 25(OH)D, has a prophylactic effect on influenza A virus infection, mice were fed a diet containing a high dose of 25(OH)D(3)and were challenged with the influenza virus. In the lungs of 25(OH)D-3-fed mice, the viral titers were significantly lower than in the lungs of standardly fed mice. Additionally, the proinflammatory cytokines IL-5 and IFN-gamma were significantly downregulated after viral infection in 25(OH)D-3-fed mice, while anti-inflammatory cytokines were not significantly upregulated. These results indicate that 25(OH)D(3)suppresses the production of inflammatory cytokines and reduces virus replication and clinical manifestations of influenza virus infection in a mouse model. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/79175 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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