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Daurichromenic Acid from the Chinese Traditional Medicinal Plant Rhododendron dauricum Inhibits Sphingomyelin Synthase and A beta Aggregation
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| Title: | Daurichromenic Acid from the Chinese Traditional Medicinal Plant Rhododendron dauricum Inhibits Sphingomyelin Synthase and A beta Aggregation |
| Authors: | Deepak, Hadya Virupaksha Browse this author | | Swamy, Mahadeva M. M. Browse this author | | Murai, Yuta Browse this author | | Suga, Yoshiko Browse this author | | Anetai, Masaki Browse this author | | Yo, Takuro Browse this author | | Kuragano, Masahiro Browse this author | | Uwai, Koji Browse this author | | Tokuraku, Kiyotaka Browse this author | | Monde, Kenji Browse this author →KAKEN DB |
| Keywords: | daurichromenic acid | | sphingomyelin synthase | | amyloid β | | dual inhibitor | | lipid-related disease |
| Issue Date: | Sep-2020 |
| Publisher: | MDPI |
| Journal Title: | Molecules |
| Volume: | 25 |
| Issue: | 18 |
| Start Page: | 4077 |
| Publisher DOI: | 10.3390/molecules25184077 |
| Abstract: | Species of the genus Rhododendron have been used in traditional Chinese medicine, with the medicinal herb "Manshanfong" used as an expectorant and for the treatment of acute bronchitis. Daurichromenic acid (DCA), a constituent of Rhododendron dauricum, is a meroterpenoid with antibacterial, anti-HIV, and anti-inflammatory activities. However, the mechanisms underlying these pharmacologic activities are poorly understood. To develop new drugs based on DCA, more information is required regarding its interactions with biomolecules. The present study showed that DCA inhibits the activity of the enzyme sphingomyelin synthase, with an IC50 of 4 mu M. The structure-activity relationships between DCA and sphingomyelin synthase were evaluated using derivatives and cyclized hongoquercin A. In addition, DCA was found to inhibit amyloid beta aggregation. These results may help in the design of effective drugs based on DCA. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/79844 |
| Appears in Collections: | 生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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