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Improvement of Glucose Tolerance by Food Factors Having Glucagon-Like Peptide-1 Releasing Activity
| Title: | Improvement of Glucose Tolerance by Food Factors Having Glucagon-Like Peptide-1 Releasing Activity |
| Authors: | Hira, Tohru Browse this author →KAKEN DB | | Trakooncharoenvit, Aphichat Browse this author | | Taguchi, Hayate Browse this author | | Hara, Hiroshi Browse this author →KAKEN DB |
| Keywords: | GLP-1 | | dietary peptides | | flavonoids |
| Issue Date: | 2021 |
| Journal Title: | International Journal of Molecular Sciences |
| Volume: | 22 |
| Issue: | 12 |
| Start Page: | 6623 |
| Publisher DOI: | 10.3390/ijms22126623 |
| Abstract: | Glucagon-like peptide-1 (GLP-1) is a gastrointestinal hormone released from enteroendocrine L cells in response to meal ingestion. GLP-1 receptor agonists and GLP-1 enhancers have been clinically employed to treat diabetes owing to their glucose-dependent insulin-releasing activity. The release of GLP-1 is primarily stimulated by macronutrients such as glucose and fatty acids, which are nutritionally indispensable; however, excessive intake of sugar and fat is responsible for the development of obesity and diabetes. Therefore, GLP-1 releasing food factors, such as dietary peptides and non-nutrients, are deemed desirable for improving glucose tolerance. Human and animal studies have revealed that dietary proteins/peptides have a potent effect on stimulating GLP-1 secretion. Studies in enteroendocrine cell models have shown that dietary peptides, amino acids, and phytochemicals, such as quercetin, can directly stimulate GLP-1 secretion. In our animal experiments, these food factors improved glucose metabolism and increased GLP-1 secretion. Furthermore, some dietary peptides not only stimulated GLP-1 secretion but also reduced plasma peptidase activity, which is responsible for GLP-1 inactivation. Herein, we review the relationship between GLP-1 and food factors, especially dietary peptides and flavonoids. Accordingly, utilization of food factors with GLP-1-releasing/enhancing activity is a promising strategy for preventing and treating obesity and diabetes. View Full-Text |
| Type: | article |
| URI: | http://hdl.handle.net/2115/84586 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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