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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Information Science and Technology / Faculty of Information Science and Technology >
Peer-reviewed Journal Articles, etc >
Insights into Mus musculus Population Structure across Eurasia Revealed by Whole-Genome Analysis
| Title: | Insights into Mus musculus Population Structure across Eurasia Revealed by Whole-Genome Analysis |
| Authors: | Fujiwara, Kazumichi Browse this author | | Kawai, Yosuke Browse this author →KAKEN DB | | Takada, Toyoyuki Browse this author →KAKEN DB | | Shiroishi, Toshihiko Browse this author →KAKEN DB | | Saitou, Naruya Browse this author →KAKEN DB | | Suzuki, Hitoshi Browse this author →KAKEN DB | | Osada, Naoki Browse this author →KAKEN DB |
| Keywords: | Mus musculus | | house mouse | | population genetics | | population demography | | genetic diversity |
| Issue Date: | 7-May-2022 |
| Publisher: | Oxford University Press |
| Journal Title: | Genome biology and evolution |
| Volume: | 14 |
| Issue: | 5 |
| Start Page: | evac068 |
| Publisher DOI: | 10.1093/gbe/evac068 |
| Abstract: | For more than 100 years, house mice (Mus musculus) have been used as a key animal model in biomedical research. House mice are genetically diverse, yet their genetic background at the global level has not been fully understood. Previous studies have suggested that they originated in South Asia and diverged into three major subspecies, almost simultaneously, approximately 110,000-500,000 years ago; however, they have spread across the world with the migration of modern humans in prehistoric and historic times (similar to 10,000 years ago to the present day) and have undergone secondary contact, which has complicated the genetic landscape of wild house mice. In this study, we sequenced the whole-genome sequences of 98 wild house mice collected from Eurasia, particularly East Asia, Southeast Asia, and South Asia. Although wild house mice were found to consist of three major genetic groups corresponding to the three major subspecies, individuals representing admixtures between subspecies were more prevalent in East Asia than has been previously recognized. Furthermore, several samples exhibited an incongruent pattern of genealogies between mitochondrial and autosomal genomes. Using samples that likely retained the original genetic components of subspecies with the least admixture, we estimated the pattern and timing of divergence among the subspecies. The estimated divergence time of the three subspecies was 187,000-226,000 years ago. These results will help us to understand the genetic diversity of wild mice on a global scale, and the findings will be particularly useful in future biomedical and evolutionary studies involving laboratory mice established from such wild mice. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/86149 |
| Appears in Collections: | 情報科学院・情報科学研究院 (Graduate School of Information Science and Technology / Faculty of Information Science and Technology) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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