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High-fluence and high-gain multilayer focusing optics to enhance spatial resolution in femtosecond X-ray laser imaging
| Title: | High-fluence and high-gain multilayer focusing optics to enhance spatial resolution in femtosecond X-ray laser imaging |
| Authors: | Yumoto, Hirokatsu Browse this author | | Koyama, Takahisa Browse this author | | Suzuki, Akihiro Browse this author →KAKEN DB | | Joti, Yasumasa Browse this author | | Niida, Yoshiya Browse this author | | Tono, Kensuke Browse this author | | Bessho, Yoshitaka Browse this author | | Yabashi, Makina Browse this author | | Nishino, Yoshinori Browse this author →KAKEN DB | | Ohashi, Haruhiko Browse this author |
| Issue Date: | 13-Sep-2022 |
| Publisher: | Nature Portfolio |
| Journal Title: | Nature communications |
| Volume: | 13 |
| Issue: | 1 |
| Start Page: | 5300 |
| Publisher DOI: | 10.1038/s41467-022-33014-4 |
| Abstract: | With the emergence of X-ray free-electron lasers (XFELs), coherent diffractive imaging (CDI) has acquired a capability for single-particle imaging (SPI) of non-crystalline objects under non-cryogenic conditions. However, the single-shot spatial resolution is limited to similar to 5 nanometres primarily because of insufficient fluence. Here, we present a CDI technique whereby high resolution is achieved with very-high-fluence X-ray focusing using multilayer mirrors with nanometre precision. The optics can focus 4-keV XFEL down to 60 nm x 110 nm and realize a fluence of >3 x 10(5) J cm(-2) pulse(-1) or >4 x 10(12) photons mu m(-2) pulse(-1) with a tenfold increase in the total gain compared to conventional optics due to the high demagnification. Further, the imaging of fixed-target metallic nanoparticles in solution attained an unprecedented 2-nm resolution in single-XFEL-pulse exposure. These findings can further expand the capabilities of SPI to explore the relationships between dynamic structures and functions of native biomolecular complexes. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/86974 |
| Appears in Collections: | 電子科学研究所 (Research Institute for Electronic Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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