|
|
Hokkaido University Collection of Scholarly and Academic Papers >
Hokkaido University Hospital >
Peer-reviewed Journal Articles, etc >
Cytokine and chemokine multiplex analysis-based exploration for potential treatment and prognostic prediction in large-vessel vasculitis : A preliminary observational study
| Title: | Cytokine and chemokine multiplex analysis-based exploration for potential treatment and prognostic prediction in large-vessel vasculitis : A preliminary observational study |
| Authors: | Abe, Nobuya Browse this author | | Kono, Michihiro Browse this author | | Kono, Michihito Browse this author | | Katsuyama, Takayuki Browse this author | | Ohmura, Kazumasa Browse this author | | Sato, Taiki Browse this author | | Karino, Kohei Browse this author | | Fujieda, Yuichiro Browse this author | | Kato, Masaru Browse this author | | Hasebe, Rie Browse this author | | Murakami, Masaaki Browse this author | | Atsumi, Tatsuya Browse this author →KAKEN DB |
| Keywords: | large vessel vasculitis | | Takayasu arteritis | | giant cell arteritis | | proteomics | | cytokine | | chemokine | | clustering | | Janus-kinase inhibitor |
| Issue Date: | 23-Nov-2023 |
| Publisher: | Frontiers Media |
| Journal Title: | Frontiers in immunology |
| Volume: | 13 |
| Start Page: | 1066916 |
| Publisher DOI: | 10.3389/fimmu.2022.1066916 |
| Abstract: | Large-vessel vasculitis (LVV) is subclassified into two phenotypes; Takayasu arteritis and giant cell arteritis. Although the pathogenesis of LVV is not fully established, IL-6-IL-17 axis and IL-12-IFN-gamma axis play critical roles in the disease development. We aimed to clarify the association between the disease state and cytokine/chemokine levels, to assess disease course as prognosis and to predict regulators in patients with LVV using the blood profiles of multiple cytokines/chemokines. This retrospective analysis comprised 35 LVV patients whose blood were collected, and multiplex cytokine/chemokine analysis with 28 analytes was performed. The differences of cytokines/chemokines corresponding disease status, upstream regulator analysis, pathway analysis and cluster analysis were conducted using the cytokines/chemokines profile. Relapse-free survival rate was calculated with Kaplan-Meier analysis in the classified clusters. In the robust analysis, IL-4, CCL2/MCP-1, TNFSF13/APRIL, TNFSF13B/BAFF, CHI3L1 and VEGF-A levels were significantly changed after treatment. Untreated LVV patients demonstrated activation of NF kappa B-related molecules and these patients are potentially treated with JAK/STAT inhibitors, anti-TNF-alpha inhibitors and IL-6 inhibitors. Cluster analysis in active LVV patients revealed two clusters including one with high blood levels of IL-1 beta, IL-6, IL-17, IL-23 and CCL20/MIP-3. A subgroup of the LVV patients showed activated IL-17 signature with high relapse frequency, and JAK/TyK2 inhibitors and IFN-gamma inhibitors were detected as potentially upstream inhibitors. Blood cytokine/chemokine profiles would be useful for prediction of relapse and potentially contributes to establish therapeutic strategy as precision medicine in LVV patients. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/87817 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
|
