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Hokkaido University Collection of Scholarly and Academic Papers >
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Cotton rats (Sigmodon hispidus) with a high prevalence of hydrocephalus without clinical symptoms
| Title: | Cotton rats (Sigmodon hispidus) with a high prevalence of hydrocephalus without clinical symptoms |
| Authors: | Kondoh, Daisuke Browse this author →KAKEN DB | | Nakamura, Teppei Browse this author →KAKEN DB | | Tsuji, Erika Browse this author | | Hosotani, Marina Browse this author →KAKEN DB | | Ichii, Osamu Browse this author →KAKEN DB | | Irie, Takao Browse this author →KAKEN DB | | Mishima, Takashi Browse this author | | Nagasaki, Ken-ichi Browse this author | | Kon, Yasuhiro Browse this author →KAKEN DB |
| Keywords: | brain ventricle | | ependymal cells | | neocortex | | pyramidal cells | | rodents |
| Issue Date: | Feb-2022 |
| Publisher: | John Wiley & Sons |
| Journal Title: | Neuropathology |
| Volume: | 42 |
| Issue: | 1 |
| Start Page: | 16 |
| End Page: | 27 |
| Publisher DOI: | 10.1111/neup.12776 |
| Abstract: | Normal-pressure hydrocephalus (NPH) is a condition in which the ventricle is enlarged without elevated cerebrospinal fluid pressure, and it generally develops in later life and progresses slowly. A complete animal model that mimics human idiopathic NPH has not yet been established, and the onset mechanisms and detailed pathomechanisms of NPH are not fully understood. Here, we demonstrate a high spontaneous prevalence (34.6%) of hydrocephalus without clinical symptoms in inbred cotton rats (Sigmodon hispidus). In all 46 hydrocephalic cotton rats, the severity was mild or moderate and not severe. The dilation was limited to the lateral ventricles, and none of the hemorrhage, ventriculitis, meningitis, or tumor formation was found in hydrocephalic cotton rats. These findings indicate that the type of hydrocephalus in cotton rats is similar to that of communicating idiopathic NPH. Histopathological examinations revealed that the inner granular and pyramidal layers (layers IV and V) of the neocortex became thinner in hydrocephalic brains. A small number of pyramidal cells were positive for Fluoro-Jade C (a degenerating neuron marker) and ionized calcium-binding adaptor molecule 1 (Iba1)-immunoreactive microglia were in contact with the degenerating neurons in the hydrocephalic neocortex, suggesting that hydrocephalic cotton rats are more or less impaired projections from the neocortex. This study highlights cotton rats as a candidate for novel models to elucidate the pathomechanism of idiopathic NPH. Additionally, cotton rats have some noticeable systemic pathological phenotypes, such as chronic kidney disease and metabolic disorders. Thus, this model might also be useful for researching the comorbidities of NPH to other diseases. |
| Rights: | This is the peer reviewed version of the following article: [Kondoh, D., Nakamura, T., Tsuji, E., Hosotani, M., Ichii, O., Irie, T., Mishima, T., Nagasaki, K.-i. and Kon, Y. (2022), Cotton rats (Sigmodon hispidus) with a high prevalence of hydrocephalus without clinical symptoms. Neuropathology, 42: 16-27. https://doi.org/10.1111/neup.12776], which has been published in final form at https://doi.org/10.1111/neup.12776. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/88152 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 中村 鉄平
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