| Title: | Impact of right ventricular reserve on exercise capacity and quality of life in patients with left ventricular assist device |
| Authors: | Takenaka, Sakae Browse this author |
| Sato, Takuma Browse this author |
| Nagai, Toshiyuki Browse this author →KAKEN DB |
| Omote, Kazunori Browse this author |
| Kobayashi, Yuta Browse this author |
| Kamiya, Kiwamu Browse this author |
| Konishi, Takao Browse this author |
| Tada, Atsushi Browse this author |
| Mizuguchi, Yoshifumi Browse this author |
| Takahashi, Yuki Browse this author |
| Naito, Seiichiro Browse this author |
| Saiin, Kohei Browse this author |
| Ishizaka, Suguru Browse this author |
| Wakasa, Satoru Browse this author →KAKEN DB |
| Anzai, Toshihisa Browse this author →KAKEN DB |
| Keywords: | exercise capacity |
| health-related quality of life |
| left ventricular assist device |
| right ventricular reserve |
| Issue Date: | Mar-2023 |
| Publisher: | American Physiological Society |
| Journal Title: | American journal of physiology. Heart and circulatory physiology |
| Volume: | 324 |
| Issue: | 3 |
| Start Page: | H355 |
| End Page: | H363 |
| Publisher DOI: | 10.1152/ajpheart.00626.2022 |
| Abstract: | Although measuring right ventricular (RV) function during exercise is more informative than assessing it at rest, the relationship between RV reserve function, exercise capacity, and health-related quality of life (HRQoL) in patients with left ventricular assist devices (LVAD) remains unresolved. We aimed to investigate whether RV reserve assessed by the change in RV stroke work index (RVSWI) during exercise is correlated with exercise capacity and HRQoL in patients with LVAD. We prospectively assessed 24 consecutive patients with LVAD who underwent invasive right heart catheterization in the supine position. Exercise capacity and HRQoL were assessed using the 6-min walk distance (6 MWD) and peak oxygen consumption (V_ O2) in cardiopulmonary exercise testing, and the EuroQol visual analog scale (EQ-VAS), respectively. The patients were divided into two groups according to the median ARVSWI (change from rest to peak exercise). Patients with lower ARVSWI had significantly lower changes in cardiac index and absolute value of RV dP/dt than those with higher ARVSWI. The ARVSWI was positively correlated with 6 MWD (r = 0.59, P = 0.003) and peak V_ O2 (r = 0.56, P = 0.006). In addition, ARVSWI was positively correlated with the EQ-VAS (r = 0.44, P = 0.030). In contrast, there was no significant correlation between RVSWI at rest and 6 MWD (r = -0.34, P = 0.88), peak V_ O2 (r = 0.074, P = 0.74), or EQ-VAS (r = 0.127, P = 0.56). Our findings suggest that the assessment of RV reserve function is useful for risk stratification in patients with LVAD. NEW & NOTEWORTHY The change in right ventricular stroke work index (RVSWI) during exercise, not RVSWI at rest, was associated with exercise capacity and HRQoL. Our findings suggest that the assessment of change in RVSWI during exercise as a surrogate of RV reserve function may aid in risk stratification of patients with LVAD. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/89314 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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