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Raman imaging of rat nonalcoholic fatty liver tissues reveals distinct biomolecular states
| Title: | Raman imaging of rat nonalcoholic fatty liver tissues reveals distinct biomolecular states |
| Authors: | Helal, Khalifa Mohammad Browse this author | | Cahyadi, Harsono Browse this author | | Taylor, J. Nicholas Browse this author | | Okajima, Akira Browse this author | | Tabata, Koji Browse this author | | Kumamoto, Yasuaki Browse this author | | Mochizuki, Kentaro Browse this author | | Itoh, Yoshito Browse this author | | Takamatsu, Tetsuro Browse this author | | Tanaka, Hideo Browse this author | | Fujita, Katsumasa Browse this author | | Komatsuzaki, Tamiki Browse this author →KAKEN DB | | Harada, Yoshinori Browse this author |
| Keywords: | nonalcoholic fatty liver | | nonalcoholic fatty liver disease | | nonalcoholic steatohepatitis | | Raman imaging |
| Issue Date: | 17-Feb-2023 |
| Publisher: | John Wiley & Sons |
| Journal Title: | FEBS Letters |
| Publisher DOI: | 10.1002/1873-3468.14600 |
| Abstract: | An essential challenge in diagnosing states of nonalcoholic fatty liver disease (NAFLD) is the early prediction of progression from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) before the disease progresses. Histological diagnoses of NAFLD rely on the appearance of anomalous tissue morphologies, and it is difficult to segment the biomolecular environment of the tissue through a conventional histopathological approach. Here, we show that hyperspectral Raman imaging provides diagnostic information on NAFLD in rats, as spectral changes among disease states can be detected before histological characteristics emerge. Our results demonstrate that Raman imaging of NAFLD can be a useful tool for histopathologists, offering biomolecular distinctions among tissue states that cannot be observed through standard histopathological means. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/89747 |
| Appears in Collections: | 電子科学研究所 (Research Institute for Electronic Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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