2024-03-29T14:59:01Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/470982023-09-28T01:41:47Zhdl_2115_20046hdl_2115_138Novel Synthesis of Optically Active Bishomotyrosine Derivatives Using the Friedel-Crafts Reaction in Triflic AcidMurai, YutaHashidoko, YasuyukiHashimoto, Makotoopen accessbishomotyrosinephenolFriedel-Crafts reactionFries rearrangementtriflic acid464We report here a novel synthesis of optically active bishomotyrosine. The bishomotyrosine skeleton was constructed by using a Friedel-Crafts reaction between phenol and optically active N-Tfa-Glu(Cl)-OMe in triflic acid under the mild condition. Reduction and subsequent deprotection then afforded bishomotyrosine derivatives without any loss of optical purity.Japan Society for Bioscience, Biotechnology, and Agrochemistry2011engjournal articleVoRhttp://hdl.handle.net/2115/47098https://doi.org/10.1271/bbb.1005950916-8451Bioscience, Biotechnology, and Biochemistry752352354https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/47098/1/bbb75_2.pdfapplication/pdf114.78 KB2011