2024-03-29T04:41:30Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/479432022-11-17T02:08:08Zhdl_2115_35410hdl_2115_35409Activity of Pursuit-Related Neurons in Medial Superior Temporal Area (MST) during Static Roll-TiltFujiwara, KeishiAkao, Teppei1000000344466Kurkin, Sergei1000070091486Fukushima, Kikuroopen accessThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in Cerebral Cortex following peer review. The definitive publisher-authenticated version Cereb. Cortex (2011) 21 (1): 155-165 is available online at: http://cercor.oxfordjournals.org/content/21/1/155coordinatemonkeyMSToptic flowpreferred directionresting ratesmooth pursuitstatic roll-tilt491Recent studies have shown that rhesus macaques can perceive visual motion-direction in earth-centered coordinates as accurately as humans. We tested whether coordinate frames representing smooth-pursuit and/or visual motion signals in MST are earth-centered to better understand its role in coordinating smooth-pursuit eye movements. In 2 Japanese macaques, we compared preferred directions (re monkeys' head/trunk axis) of pursuit and/or visual motion responses of MSTd neurons while upright and during static whole-body roll-tilt. In the majority (41/51 = 80%) of neurons tested, preferred directions of pursuit and/or visual motion responses were similar while upright and during 40° static roll-tilt. Preferred directions of the remaining 20% of neurons (n = 10) were shifted beyond the range expected from ocular counter-rolling; the maximum shift was 14° and the mean shift was 12°. These shifts, however, were still less than half of the expected shift if MST signals are coded in the earth-centered coordinates. Virtually, all tested neurons (44/46 = 96%) failed to exhibit a significant difference between resting discharge rate while upright and during static roll-tilt while fixating a stationary spot. These results suggest that smooth-pursuit and/or visual motion signals of MST neurons are not coded in the earth-centered coordinates We suggest that these signals are coded in the head-centered coordinate.Oxford University Press2011-01engjournal articleAMhttp://hdl.handle.net/2115/47943https://doi.org/10.1093/cercor/bhq0721047-3211Cerebral Cortex211155165https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/47943/1/CC21-1_155-165.pdfapplication/pdf910.15 KB2011-01