2024-03-29T08:51:39Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/495642022-11-17T02:08:08Zhdl_2115_20049hdl_2115_141Liposomal sn-2 DHA inserted phospholipid decreases tumor size of fibrosarcomaFujimoto, AkihitoSasaki, Jin-ichi1000010241374Hosokawa, Masashi1000090125328Takahashi, Koretaroopen access© 2002 公益社団法人日本水産学会© 2002 The Japanese Society of Fisheries Sciencephospholipidliposomefibrosarcomaphagocytosisantitumor663Liposomes especially the multilamella vesicles (MLV) are known to be phagocyted by macrophages. This was considered to be a problem when designing a drug delivery system. If we take another way of looking at this problem, we could take advantage of this draw back of MLV. For instance, by encapsulating a biological response modifier, we may activate macrophages. The sn-2 docosahexaenoic acid (DHA) inserted phospholipids (2-DHA-PL) have been receiving attentions on their boosting effects on functional compounds such as retinoid or hormones without any serious side effect. For this reason, it is expected to enhance therapeutic effects of the encapsulated compound. In this study, we evaluated the antitumor activity of 2-DHA-PL liposome against Meth-A fibrosarcoma both in vitro and in vivo.Japanese Society of Fisheries Science2002engjournal articleVoRhttp://hdl.handle.net/2115/49564https://doi.org/10.2331/fishsci.68.sup2_16390919-9268AA10993718Fisheries Science68216391640https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/49564/1/FS68_1639.pdfapplication/pdf1.35 MB2002