2024-03-29T06:05:57Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/510682022-11-17T02:08:08Zhdl_2115_35410hdl_2115_35409A Simulation Study of the Radiation-Induced Bystander Effect : Modeling with Stochastically Defined Signal ReemissionSasaki, KoheiWakui, Kosuke1000080344505Tsutsumi, KaoriItoh, Akio1000010197600Date, Hiroyukiopen accessCreative Commons Attribution 3.0 Unported492The radiation-induced bystander effect (RIBE) has been experimentally observed for different types of radiation, cell types, and cell culture conditions. However, the behavior of signal transmission between unirradiated and irradiated cells is not well known. In this study, we have developed a new model for RIBE based on the diffusion of soluble factors in cell cultures using a Monte Carlo technique. The model involves the signal emission probability from bystander cells following Poisson statistics. Simulations with this model show that the spatial configuration of the bystander cells agrees well with that of corresponding experiments, where the optimal emission probability is estimated through a large number of simulation runs. It was suggested that the most likely probability falls within 0.63-0.92 for mean number of the emission signals ranging from 1.0 to 2.5.Hindawi Publishing Corporation2012engjournal articleVoRhttp://hdl.handle.net/2115/51068https://doi.org/10.1155/2012/3890951748-670XComputational and Mathematical Methods in Medicine2012389095https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/51068/1/CMMM2012_389095.pdfapplication/pdf1.25 MB2012