2024-03-29T01:09:13Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/56582022-11-17T02:08:08Zhdl_2115_20051hdl_2115_144The DNA-based gels for oral delivery of probiotic bacteriaJonganurakkun, Benjamasジョンアヌラックン, ベンジャマートNodasaka, Yoshinobu1000060153863Sakairi, NobuoNishi, Norioopen accessbiomaterialsDNAhydrogelsprobiotic strainsdrug delivery system578Published in Macromolecular Bioscience, 2006, Wiiley-VCH Verlag GmbH & Co. KGaA, WeinheimA single-stranded DNA readily extracted from industrial discarded salmon milt, was used to prepare hydrogels and complex gels by cross-linking with gelatin and κ-carrageenan, for the oral delivery of probiotic bacteria. The complex gels showed a higher protective capability over the hydrogels for approximately one log scale. However, the hydrogels were more stable during 4°C storage. The Lactobacillus and Lactococcus due to protection of the hydrogels could better tolerate to acid than the Bifidobacterium. Furthermore, food-graded hydrogels were prepared and optimized to a similar protective capability for future applications.WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim2006-01-05engjournal articleVoRhttp://hdl.handle.net/2115/5658http://www.interscience.wiley.com/https://doi.org/10.1002/mabi.200500199163747761616-5187Macromolecular Bioscience6199103https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/5658/1/MB6-1.pdfapplication/pdf408.55 KB2006-01-05