2024-03-29T06:25:25Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/630862022-11-17T02:08:08Zhdl_2115_20058hdl_2115_149Constitutive aryl hydrocarbon receptor signaling constrains type I interferon–mediated antiviral innate defenseYamada, TaishoHorimoto, Hiromasa1000040569505Kameyama, TakeshiHayakawa, SumioYamato, HiroakiDazai, Masayoshi1000010292062Takada, Ayato1000010109506Kida, HiroshiBott, DebbieZhou, Angela CHutin, DavidWatts, Tania H1000010113507Asaka, MasahiroMatthews, Jason1000030323611Takaoka, Akinoriopen access490Supplementary materials are available on the publisher's website.Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxic activity of many environmental xenobiotics. However, its role in innate immune responses during viral infection is not fully understood. Here we demonstrate that constitutive AHR signaling negatively regulates the type I interferon (IFN-I) response during infection with various types of virus. Virus-induced IFN-β production was enhanced in AHR-deficient cells and mice and resulted in restricted viral replication. We found that AHR upregulates expression of the ADP-ribosylase TIPARP, which in turn causes downregulation of the IFN-I response. Mechanistically, TIPARP interacted with the kinase TBK1 and suppressed its activity by ADP-ribosylation. Thus, this study reveals the physiological importance of endogenous activation of AHR signaling in shaping the IFN-I-mediated innate response and, further, suggests that the AHR-TIPARP axis is a potential therapeutic target for enhancing antiviral responses.Nature Publishing Group2016-06engjournal articleAMhttp://hdl.handle.net/2115/63086https://doi.org/10.1038/ni.3422270893811529-29081529-2916AA11466707Nature Immunology176687694https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/63086/3/NatImmunol17_687.pdfapplication/pdf3.34 MB2016-06