2024-03-28T08:32:41Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/700262022-11-17T02:08:08Zhdl_2115_20039hdl_2115_116Iron chelators inhibit the heme-degradation reaction by HutZ from Vibrio choleraeDojun, NobuhikoSekine, Yukari1000020192487Ishimori, Koichiro1000030343742Uchida, Takeshiopen access430HutZ is a heme-degrading enzyme. We found that the heme-degradation reaction by HutZ is inhibited by the iron chelators. Kinetic analysis of each heme-degradation step suggests that water molecules hydrogen bonded to Thr27 are involved in proton transfer to Fe(III)-OO-, and that this step is inhibited by iron chelators.Royal Society of Chemistry2017-04-28engjournal articleAMhttp://hdl.handle.net/2115/70026https://doi.org/10.1039/c7dt00121e283529091477-92261477-9234AA11810256Dalton transactions461651475150https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/70026/1/Dojun-Dalton.pdfapplication/pdf837.31 KB2017-04-28