2024-03-28T12:27:13Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/706452022-11-17T02:08:08Zhdl_2115_20040hdl_2115_121Refining prognosis in patients with hepatocellular carcinoma through incorporation of metabolic imaging biomarkersTakeuchi, SatoshiRohren, Eric M.Abdel-Wahab, RehamXiao, LianchunMorris, Jeffrey S.Macapinlac, Homer A.Hassan, Manal M.Kaseb, Ahmed O.open accessThe final publication is available at link.springer.comFDG PET/CTHepatocellular carcinomaCLIP scoring systemBCLC staging system490Purpose: 18F-fluorodeoxyglucose positron emission tomopraphy/computed tomography (FDGPET/CT) has been proven to be useful for imaging many types of cancer; however, its role is not well defined in hepatocellular carcinoma (HCC). We assessed the prognostic value of metabolic imaging biomarkers as established by baseline pretreatment FDG PET/CT in patients with HCC. Methods: We retrospectively analyzed the records of patients with HCC who underwent FDG PET/CT before initial treatment from May 2013 through May 2014. Four PET/CT parameters were measured: maximum standardized uptake value (SUVmax), total lesion glycolysis (TLG), metabolic tumor volume (MTV), and tumor-to-normal-liver SUV ratio (TNR). Optimal cut-off values for the PET/CT parameters to stratify patients in terms of overall survival (OS) were determined. Multivariate analysis was performed to determine whether the PET/CT parameters could add to the prognostic value of the Cancer of the Liver Italian Program (CLIP) scoring system and the Barcelona-Clinic Liver Cancer (BCLC) staging system. Results: The analysis included 56 patients. Univariate analysis of the association between OS and continuous variables, including the PET/CT parameters SUVmax, TLG, tumor size, total bilirubin level, and alkaline phosphatase level were significant predictors of OS. SUVmax ≥ 11.7, TLG ≥ 1,341, MTV ≥ 230 mL, and TNR ≥ 4.8 were identified as cut-off values. Multivariate analysis revealed that SUVmax ≥ 11.7 and TNR ≥ 4.8 were independent factors predicting a poor prognosis in both the CLIP scoring system and the BCLC staging system, as was TLG in the BCLC staging system. Conclusion: Pretreatment FDG PET/CT in patients with HCC can add to the prognostic value of standard clinical measures. Incorporation of imaging biomarkers derived from FDG PET/CT into HCC staging systems should be considered.Springer2017-06engjournal articleAMhttp://hdl.handle.net/2115/70645https://doi.org/10.1007/s00259-016-3583-21619-7070European Journal of Nuclear Medicine and Molecular Imaging446969978https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/70645/1/EurJNuclMedMolImaging44_969.pdfapplication/pdf484.16 KB2017-06