2024-03-28T23:27:59Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/868952022-11-17T02:08:08Zhdl_2115_20048hdl_2115_140Early-phase migration dynamics of Echinococcus multilocularis in two mouse strains showing different infection susceptibilitiesHayashi, NaokiKouguchi, HirokazuImasato, YuheiIrie, Takao1000070414323Yagi, Kinpei1000050281853Nonaka, Nariaki1000050633955Nakao, Ryoopen access© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 InternationalEchinococcus multilocularisMigration dynamicsOncospheresPrimary alveolar echinococcosisqPCR649The early-phase migration dynamics of Echinococcus multilocularis in the intermediate hosts remain largely unknown. We compared the parasite burden in the intestine, liver and faeces of DBA/2 and C57BL/6 mouse strains using parasite-specific quantitative PCR. Our results indicated that the parasites invaded mainly from the middle segments of the small intestine and completed migration to the liver within 24 h p.i. C57BL/6 mice had lower parasite DNA burdens in the intestine and liver but higher in the faeces than DBA/2 mice, suggesting that parasite invasion of the intestine may be a critical stage regulating susceptibility to E. multilocularis infection in mice. (c) 2021 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.Elsevier2021-10-01engjournal articleAMhttp://hdl.handle.net/2115/86895https://doi.org/10.1016/j.ijpara.2021.04.0010020-7519International journal for parasitology5111893898https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/86895/1/International%20journal%20for%20parasitology51%20%2811%29_893-898.pdfapplication/pdf498.85 KB2021-10-01