2024-03-28T09:46:59Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/171242022-11-17T02:08:08Zhdl_2115_20045hdl_2115_139Drastic change of local stiffness distribution correlating to cell migration in living fibroblasts.Nagayama, MasafumiHaga, HisashiKawabata, Kazushigescanning probe microscopyforce modulation modeactin filamentsNIH3T3cell movement463Sequential images of the local stiffness distribution of living fibroblasts (NIH3T3) were captured under a culture condition using scanning probe microscopy in a force modulation mode. We found a clear relation between cell migration and local stiffness distribution on the cell: When cells were stationary at one position, the stiffness distribution of their cellular surface was quite stable. On the other hand, once the cells started to move, the stiffness in their nuclear regions drastically decreased. Possible explanations for the correlation between the cell migration and the cell stiffness are proposed. Cell Motil. Cytoskeleton 50:173-179, 2001. © 2001 Wiley-Liss, Inc.Wiley-Liss, Inc.Journal Articleapplication/pdfhttp://hdl.handle.net/2115/17124https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/17124/1/CMC_HUSCAP.pdf0886-15441097-0169Cell Motility and the Cytoskeleton5041731792001-12enginfo:pmid/11807938info:doi/10.1002/cm.10008Copyright © 2001 John Wiley & Sons, Inc., Cell Motility and the Cytoskeleton, volume 50, issue 4, pp. 173-179author