2024-03-29T11:34:02Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/172422023-08-28T02:21:14Zhdl_2115_20043hdl_2115_137分子生物学的に同一クローンの再発を確認しえた biphenotypic leukemiaRelapse of biphenotypic leukemia confirmed by molecular study小野澤, 真弘橋野, 聡泉山, 康米積, 昌克千葉, 広司近藤, 健田中, 淳司今村, 雅寛浅香, 正博Biphenotypic leukemiaMinimal residual diseaseT-cell receptor rearrangement193.29A 60-year-old woman was admitted to our hospital to receive treatment for relapse of biphenotypic leukemia 4 years after initial presentation. Bone marrow examination revealed 53.5% lymphoblasts, which were classified as ALL-L2 with normal karyotype. Surface markers of lymphoblasts were positive for both B-cell and myeloid lineage. Immunoglobulin heavy chain and T-cell receptor gene rearrangements were investigated by PCR. Clonal rearrangement of TCRδ Vδ2-Dδ3 was detected. The same clonal rearrangement of TCRδ was found using frozen initial leukemic cells. Her leukemia was confirmed as not secondary leukemia but relapse of the initial clone. Detection of the rearrangement was also useful as a patient-specific marker for minimal residual disease.日本臨床血液学会Journal Articleapplication/pdfhttp://hdl.handle.net/2115/17242https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/17242/1/rinshoketsueki45-2.pdf0485-1439臨床血液4521611632004-02-29jpnauthor