2024-03-28T19:14:17Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/220952022-11-17T02:08:08Zhdl_2115_20048hdl_2115_140Antitumor effects and blood flow dynamics after photodynamic therapy using benzoporphyrin derivative monoacid ring A in KLN205 and LM8 mouse tumor modelsOsaki, TomohiroTakagi, SatoshiHoshino, YukiOkumura, MasahiroFujinaga, ToruPhotodynamic therapyBenzoporphyrin derivative monoacid ring APower Doppler ultrasound649Photodynamic therapy (PDT) using benzoporphyrin derivative monoacid ring A (BPD-MA) induces direct tumor cell damage and microvascular injury. We administered BPD-MA at 3 h or 15 min before laser irradiation to KLN205 and LM8 tumors in murine models. Tumor growth delay was induced more effectively by 15-min-interval PDT than by 3-h-interval PDT. Vascularity and blood perfusion was significantly decreased by 15-min-interval PDT. We observed death of all tumor cells, except peripheral cells, in the 3-h-interval PDT group, and death of cells around the damaged tumor vasculature in the 15-min-interval PDT group. Thus, 15-min-interval PDT enhanced the antitumor effect by damaging tumor vasculature.ElsevierJournal Articleapplication/pdfhttp://hdl.handle.net/2115/22095https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/22095/1/CL248-1.pdf0304-3835Cancer Letters248147572007-04-08enginfo:pmid/16837129info:doi/10.1016/j.canlet.2006.05.021author