2024-03-28T20:57:28Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/452482022-11-17T02:08:08Zhdl_2115_20046hdl_2115_138A partially degraded product of phytate suppresses the proliferation of HCT116 colorectal cancer cellsIshizuka, SatoshiSaitoh, Ken-ichiSuzuki, TakuyaLee, Jae-SungHara, HiroshiCell proliferation5-bromo-2'-deoxyuridineHCT116 cellsPhytate hydrolysate498Phytate, myo-inositol hexaphosphate (IP6), has been shown to possess anti-carcinogenic qualities. IP6 appears to be partially digested in the digestive tract and degraded into inositol di, tri-, and tetra-phosphate (IP2, IP3, and IP4). The present study investigated whether IP3-rich phytate hydrolysate (IP3-RPH), a partially degraded product from phytate plays a role in the suppression of cell proliferation using an HCT116 colon carcinoma cell line. IP3-RPH suppresses cell proliferation as well as IP6, and the suppression activity of IP3-RPH was higher than that of IP6. Suppression modes clearly differed between IP3-RPH and IP6. Our findings suggest that partially degraded IP6 products are responsible for the suppression of colon carcinogenesis by IP6.ElsevierJournal Articleapplication/pdfhttp://hdl.handle.net/2115/45248https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/45248/1/FC125-4_1219-1225.pdf0308-8146Food Chemistry1254121912252011-04-15enginfo:doi/10.1016/j.foodchem.2010.10.037author