2024-03-29T12:09:47Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/469702022-11-17T02:08:08Zhdl_2115_20044hdl_2115_124Synthesis of Cyclic ADP-Carbocylcic-Xylose and its 3′′-OO-Methyl Analogue as Stable and Potent Ca2+-Mobilizing AgentsKudoh, TakashiMatsuda, AkiraShuto, SatoshiMurayama, TakashiOgawa, Yasuo464We previously showed that 3”-deoxy-cyclic ADP-carbocyclic-ribose (3”-deoxy-cADPcR, 2) is a stable and highly potent analogue of cyclic ADP-ribose (cADPR, 1), a Ca2+-mobilizing second messenger. From these results, we newly designed another 3”-modified analogues of cADPcR and identified the N1-“xylo”-type carbocyclic analogue, i.e., cADPcX (4), as one of the most potent cADPR-related compounds reported so far.Taylor & FrancisJournal Articleapplication/pdfhttp://hdl.handle.net/2115/46970https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/46970/1/366_NsNt%20Kudo.pdf1525-77701532-2335Nucleosides, Nucleotides and Nucleic Acids254-65835992006-04enginfo:pmid/16838847info:doi/10.1080/15257770600685867This is an electronic version of an article published in Nucleosides, Nucleotides & Nucleic Acids, 25(4/6), 583-599, 2006. Nucleosides, Nucleotides & Nucleic Acids is available online at: http://www.informaworld.com/openurl?genre=article&issn=15257770&volume=25&issue=4-6&spage=583author