2024-03-28T16:27:56Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/487192022-11-17T02:08:08Zhdl_2115_20043hdl_2115_137Performance characterization of the Inveon preclinical small-animal PET/SPECT/CT system for multimodality imagingMagota, KeiichiKubo, NaokiKuge, YujiNishijima, Ken-ichiZhao, SongjiTamaki, NagaraIntegrated PET/SPECT/CT systemSmall-animal imagingPerformance measurementInstrumentationMolecular imaging492Purpose: We analyzed the performance of the Inveon for an integrated small-animal PET/SPECT/CT system and compared the imaging capabilities of the SPECT and the PET components. Methods: For SPECT, energy resolution, tomographic spatial resolution, and system sensitivity were evaluated with 99mTc solution using a single pinhole collimator. For PET, spatial resolution, absolute sensitivity, scatter fraction, and peak noise equivalent count (NEC) were evaluated. A micro-Derenzo phantom, cylindrical phantom, and National Electrical Manufacturers Association NU-4 image quality phantom were scanned to compare SPECT and PET image capabilities, and SPECT and PET bone imaging were performed on a normal rat in vivo. Results: SPECT spatial resolution was 0.84 mm full width at half maximum (FWHM) at a radius of rotation of 25 mm using the 0.5-mm pinhole aperture collimator, while PET spatial resolution was 1.63 mm FWHM at the center. SPECT system sensitivity at a radius of rotation of 25 mm was 35.3 cps/MBq (4 × 10^[-3]%) using 0.5-mm pinhole aperture, while PET absolute sensitivity was 3.2% for 350-650 keV and 3.432 ns. Accordingly, the volume sensitivity of PET was three orders of magnitude higher than that of SPECT. Conclusions: This integrated PET/SPECT/CT system provided high system performance with excellent spatial resolution for SPECT and sensitivity for PET. Based on tracer availability and system performance, SPECT and PET have complementary roles for multi-modality small-animal imaging.Springer Berlin / HeidelbergJournal Articleapplication/pdfhttp://hdl.handle.net/2115/48719https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/48719/1/EJNMMI38-4_742-752.pdf1619-7070European Journal of Nuclear Medicine and Molecular Imaging3847427522011-04enginfo:pmid/21153410info:doi/10.1007/s00259-010-1683-yThe original publication is available at www.springerlink.comauthor