2024-03-28T12:50:02Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/526842022-11-17T02:08:08Zhdl_2115_20040hdl_2115_121TAMable tumor-associated macrophages in response to innate RNA sensingSeya, TsukasaShime, HiroakiMatsumoto, MisakoTLR3TICAM-1tumor-infiltrating macrophagespolyI:Cimmunotherapy491Antitumor effect of PolyI: C (a viral dsRNA analog) has been attributed to dendritic cell (DC)-maturation activity, that drives antitumor NK cells, DC cross-presentation, cytotoxic T lymphocytes and many IFN-inducible genes. According to a recent paper, tumor-infiltrating M2 macrophages are found to become an additional antitumor effector through polyI: C response.LANDES BIOSCIENCEJournal Articleapplication/pdfhttp://hdl.handle.net/2115/52684https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/52684/1/TAMable%20Mf%20rev-3.pdf2162-4011OncoImmunology16100010012012-09enginfo:doi/10.4161/onci.19894author