2024-03-28T14:16:12Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/529892022-11-17T02:08:08Zhdl_2115_20051hdl_2115_144Effects of parabens on apoptosis induced by serum-free medium.Egawa, MariAoki, KentaroSun, YongkunHosokawa, ToshiyukiSaito, TakeshiKurasaki, MasaakiPC12 cellendocrine disrupterfood additivesapoptotic factorsmethylparabenbutylparaben498Alkyl esters of p-hydroxybenzoic acids (parabens), an endocrine disrupter, are used as preservatives in cosmetics and foods. In this study, to understand the relationship between parabens and differentiation in infants, the effects of parabens on apoptosis induced by serum deprivation in PC12 cells were investigated. In addition, apoptosis-related factors were assayed. As results, a tendency toward enhancement of apoptosis was observed in the cells cultured in the serum-free medium with methylparaben, and this tendency was suggested to be related to the contents of BAD, a pro-apoptotic protein. Butylparaben did not show any tendency to enhance apoptosis.Taylor & FrancisJournal Articleapplication/pdfhttp://hdl.handle.net/2115/52989https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/52989/1/Ms%23B1471f_BW.pdf0360-12341532-4109AA00697424Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes4731962042012-03enginfo:pmid/22375591info:doi/10.1080/03601234.2012.634341This is an Author's Accepted Manuscript of an article published in Journal of Environmental Science and Health, Part B Pesticides, Food Contaminants, and Agricultural Wastes, Vol. 47, Iss. 3, 2012, copyright Taylor & Francis, available online at: http://www.tandfonline.com/10.1080/03601234.2012.634341.author