2024-03-29T02:22:43Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/533432022-11-17T02:08:08Zhdl_2115_20042hdl_2115_136Bone Augmentation Using Novel Unidirectional Porous Hydroxyapatite with Bone Morphogenetic Protein-2 on Rat SkullKashiwazaki, HaruhikoHarada, NaokiAkazawa, ToshiyukiKabir, Md. ArafatMinamida, YasuhitoMurata, MasaruUnidirectional porous hydroxyapatite (UDPHAp)Onlay graftBone augmentationRecombinant human bone morphogenetic protein-2 (rhBMP-2)497Unidirectional porous hydroxyapatite (UDPHAp) is a material whose microstructure consists of cross-sectional oval pores with a pore diameter in the range of 100-300 mu m that penetrate through the material. UDPHAp has proven suitable for osteogenesis and angiogenesis. The present study was designed to evaluate the osteogenic effect of a newly developed UDPHAp as a carrier of recombinant human bone morphogenetic protein-2 (rhBMP-2) in a rat onlay graft model. UDPHAp was implanted beneath the calvarial periosteum of rats to simulate alveolar bone augmentation in a clinical condition. At 2 weeks after implantation, UDPHAp with rhBMP-2 resulted in active bone formation, and the augmented bone was connected directly with the original bone, whereas commercialized porous hydroxyapatite (PHAp) with rhBMP-2 showed little bone formation. These results suggest that UDPHAp in this model is suitable for onlay graft and is an effective biomaterial for the rhBMP-2 delivery system.Journal hard tissue biologyJournal Articleapplication/pdfhttp://hdl.handle.net/2115/53343https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/53343/1/62533_pdf.pdf1341-7649AA11074332Journal of hard tissue biology2233373412013-07enginfo:doi/10.2485/jhtb.22.337publisher