2024-03-29T01:08:13Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/540302022-11-17T02:08:08Zhdl_2115_20048hdl_2115_140Susceptibility to flavivirus-specific antiviral response of Oas1b affects the neurovirulence of the Far-Eastern subtype of tick-borne encephalitis virusYoshii, KentaroMoritoh, KanakoNagata, NoriyoYokozawa, KanaSakai, MizukiSasaki, NobuyaKariwa, HiroakiAgui, TakashiTakashima, Ikuo498Tick-borne encephalitis virus (TBEV) is a zoonotic agent that causes fatal encephalitis in humans. 2'-5'-oligoadenylate synthetase 1b (Oas1b) has been identified as a flavivirus resistance gene, but most inbred laboratory mice do not possess a functional Oas1b gene. In this study, a congenic strain carrying a functional Oas1b gene, B6.MSM-Oas, was used to evaluate the pathogenicity of Far-Eastern TBEV. Although intracerebral infection of B6.MSM-Oas mice by Oshima 5-10 resulted in limited signs of illness, infection by Sofjin-HO resulted in death with severe neurologic signs. While Oshima 5-10 was cleared from the brain, Sofjin-HO was not cleared despite a similar level of expression of the intact Oas1b gene. Necrotic neurons with viral antigens and inflammatory reactions were observed in the brain infected with Sofjin-HO. These data indicate that the different susceptibility to the antiviral activity of Oas1b resulted in a difference in neurovirulence in the two TBEV strains.SpringerJournal Articleapplication/pdfhttp://hdl.handle.net/2115/54030https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/54030/1/Oas%20ic%20paper%20for%20Arch%20virol%20revised2.pdf0304-8608Archives of Virology1585103910462013-05enginfo:pmid/23266832info:doi/10.1007/s00705-012-1579-1author