2024-03-29T15:28:53Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/584352022-11-17T02:08:08Zhdl_2115_20043hdl_2115_137Spontaneous regression of small cell lung cancer combined with cancer associated retinopathyKitai, HidenoriSakakibara-Konishi, JunOizumi, SatoshiHirohashi, YoshihikoSaito, WataruKanda, AtsuhiroSato, NoriyukiNishimura, MasaharuSmall cell lung cancerCancer associated retinopathySpontaneous regressionRecoverinCytotoxic T lymphocytesImmnologic reaction490Spontaneous regression (SR) is defined as the complete or partial disappearance of disease without anticancer treatments. We report a case of SR of small cell lung cancer (SCLC) combined with cancer associated retinopathy (CAR). A 65-year-old woman was admitted to our hospital to examine abnormal shadows of the lung with visual loss. She was diagnosed with SCLC associated with CAR. Subsequent chest X-ray and CT scan showed partial regression of both primary tumor and lymph node metastasis without anticancer treatment. Recoverin antigen was present on the tumor cells and anti-recoverin antibody was observed in the patient's serum. Activation of recoverin-specific antitumor cytotoxic T lymphocyte (CTL) was observed in this patient. SCLC was considered to reduce spontaneously by the activation of recoverin-specific antitumor CTL. To the best of our knowledge, this is the first report of SR in SCLC combined with CAR. (C) 2014 Elsevier Ireland Ltd. All rights reserved.Elsevier IrelandJournal Articleapplication/pdfhttp://hdl.handle.net/2115/58435https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/58435/1/revised_manuscript.pdf0169-5002Lung Cancer87173762015-01enginfo:pmid/25468200info:doi/10.1016/j.lungcan.2014.10.015author