2024-03-28T10:24:10Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/634732023-10-05T04:10:28Zhdl_2115_20058hdl_2115_149Oral administration of the β-glucan produced by Aureobasidium pullulans ameliorates development of atherosclerosis in apolipoprotein E deficient miceAoki, ShihoIwai, AtsushiKawata, KojiMuramatsu, DaisukeUchiyama, HirofumiOkabe, MitsuyasuIkesue, MasahiroMaeda, NaoyoshiUede, Toshimitsuβ-glucanAureobasidium pullulansAtherosclerosis491The Aureobasidium pullulans-produced β-glucan (AP-PG) is an immune stimulator, and believed to exhibit beneficial effects on health through its immune stimulating activity. Here, the effect of oral administration of AP-PG on high-fat diet (HFD)-induced atherosclerosis was evaluated using apolipoprotein E deficient mice, a widely used mouse model for atherosclerosis. The results demonstrated that HFD-induced development of atherosclerosis was significantly reduced in the AP-PG-treated mice when compared with that of the control mice. In serological analysis, blood levels of oxidized low-density lipoprotein cholesterol, a well-known risk factor for the development of atherosclerosis, were significantly reduced in the AP-PG-treated group of mice. Further, immunohistochemical analysis using MOMA-2 antibody showed that oral administration of AP-PG is effective in ameliorating vascular accumulation of macrophages. These data suggest the possibility that oral administration of AP-PG is effective in ameliorating HFD-induced development of atherosclerosis.ElsevierJournal Articleapplication/pdfapplication/pdfhttp://hdl.handle.net/2115/63473https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/63473/1/manuscript%28Aoki_et_al_CAD%29.pdfhttps://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/63473/2/supplemental%20information%28Aok_et_al_CAD%29.pdf1756-4646Journal of Functional Foods1822272015-10enginfo:doi/10.1016/j.jff.2015.06.044© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/author