2024-03-29T05:28:44Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/651942023-07-10T03:50:30Zhdl_2115_20039hdl_2115_116Site-Selective and Stereoselective C(sp(3))-H Borylation of Alkyl Side Chains of 1,3-Azoles with a Silica-Supported Monophosphine-Iridium CatalystMurakami, RyoIwai, TomohiroSawamura, Masaya1,3-azoleC-H activationborylationiridiumheterogeneous catalyst400Site-selective and stereoselective C(sp(3))-H borylation of alkyl side chains of 1,3-azoles with bis(pinacolato) diboron was effectively catalyzed by a silica-supported monophosphine-iridium catalyst. The borylation occurred under relatively mild conditions (2 mol% Ir, 5090 degrees C), affording the corresponding primary and secondary alkylboronates. This system was applicable to a variety of 1,3-(benzo) azoles such as thiazoles, oxazoles, and imidazoles.Georg Thieme VerlagJournal Articleapplication/pdfhttp://hdl.handle.net/2115/65194https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/65194/1/Manuscript_revised_ver1.0_HUSCAP.pdf0936-5214Synlett278118711922016-05enginfo:doi/10.1055/s-0035-1561599author