2024-03-28T22:55:00Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/669382022-11-17T02:08:08Zhdl_2115_20046hdl_2115_138Isolation of rugosin A, B and related compounds as dipeptidyl peptidase-IV inhibitors from rose bud extract powderKato, EisukeUenishi, YutaInagaki, YosukeKurokawa, MihokoKawabata, Jundipeptidyl peptidase IVdiabetesellagitanninRosa gallica498Dipeptidyl peptidase-IV (DPP-IV) is a protease responsible for the degradation of the incretin hormone. A number of DPP-IV inhibitors have been approved for use in the treatment of type 2 diabetes. While these inhibitors are effective for this treatment, methods for the prevention of this disease are also required as diabetes patient numbers are currently increasing rapidly worldwide. We screened the DPP-IV inhibitory activities of edible plant extracts with the intention of using these extracts in a functional food supplement for the prevention of diabetes. Rose (Rosa gallica) bud extract powder was a promising material with high inhibitory activity. In this study, seven ellagitannins were isolated as active compounds through activity-guided fractionations, and their DPP-IV inhibitory activities were measured. Among them, rugosin A and B showed the highest inhibitory activities and rugosin B was shown as the major contributing compound in rose bud extract powder.Taylor & FrancisJournal Articleapplication/pdfapplication/pdfhttp://hdl.handle.net/2115/66938https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/66938/1/Biosci.%20Biotechnol.%20Biochem.80-11_2087-2092.pdfhttps://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/66938/2/tbbb_a_1214533_sm1895.pdf0916-84511347-6947AA10824164Bioscience biotechnology and biochemistry8011208720922016-08enginfo:pmid/27477520info:doi/10.1080/09168451.2016.1214533This is an Accepted Manuscript of an article published by Taylor & Francis in Bioscience biotechnology and biochemistry on 01 Aug 2016, available online: http://www.tandfonline.com/doi/full/10.1080 /09168451.2016.1214533author