2024-03-28T16:36:14Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/683352022-11-17T02:08:08Zhdl_2115_20043hdl_2115_137Primary malignant melanoma of the esophagus treated with subtotal esophagectomy : a case reportKuwabara, ShotaEbihara, YumaNakanishi, YoshitsuguAsano, ToshimichiNoji, TakehiroKurashima, YoMurakami, SoichiNakamura, ToruTsuchikawa, TakahiroOkamura, KeisukeShichinohe, ToshiakiHirano, SatoshiEsophagusMelanomaPathologyTreatmentPrognosis490Background: Primary malignant melanoma of the esophagus (PMME) is a rare disease with a poor prognosis. There are few reports of early-stage cases in which tumor invasion reached the lamina propria or muscularis mucosae, as in the present case. A standard treatment for early-stage PMME has not yet been established. The present study aimed to summarize previous reports and to discuss the indications for surgical treatment of early-stage primary malignant melanoma of the esophagus. Case presentation: A 70-year-old woman with PMME was referred to our hospital. She underwent thoracoscopic and laparoscopic subtotal esophagectomy with lymphadenectomy. The resected specimen showed melanocytosis and junctional activity. Melanoma-specific antigens melan-A, S-100, and HMB45 were detected by immunohistochemical staining. The pathological diagnosis was pT1a-MM, pN0, pM0, and pStage IA. She remains alive without evidence of recurrence 39 months later. Conclusion: Subtotal esophagectomy with regional radical lymphadenectomy could be recommended to patients with early-stage primary malignant melanoma of the esophagus, and curative surgical resection could improve their prognosis.BioMed CentralJournal Articleapplication/pdfhttp://hdl.handle.net/2115/68335https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/68335/1/s12893-017-0326-7.pdf1471-2482BMC surgery171222017-12-02enginfo:doi/10.1186/s12893-017-0326-7http://creativecommons.org/licenses/by/4.0/publisher