2024-03-29T14:58:30Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/706672022-11-17T02:08:08Zhdl_2115_20048hdl_2115_140Serial measurement of pancreatic lipase immunoreactivity concentration in dogs with immune-mediated disease treated with prednisoloneOhta, H.Morita, T.Yokoyama, N.Osuga, T.Sasaki, N.Morishita, K.Nakamura, K.Takiguchi, M.649Objectives: In this pilot study, serum canine pancreatic lipase immunoreactivity was measured repeatedly in dogs with various immune-mediated diseases that were treated with immunosuppressive doses of prednisolone. Methods: Ten client-owned dogs with newly diagnosed immune-mediated disease that had normal canine pancreatic lipase immunoreactivity concentrations (200 mu g/l) were treated with 2 to 2.2 mg/kg prednisolone orally once daily as the initial treatment. Serum samples were obtained from each of the dogs prior to treatment and at 1- to 4-week intervals during immunosuppressive treatment. The highest canine pancreatic lipase immunoreactivity concentration detected during immunosuppressive treatment was defined as the peak canine pancreatic lipase immunoreactivity. Results: Peak canine pancreatic lipase immunoreactivity concentrations were classified as normal in two dogs, questionable (201 to 399 mu g/l) in three dogs, and abnormal (≥400 mu g/l) in five dogs. Peak canine pancreatic lipase immunoreactivity concentrations were significantly higher than baseline canine pancreatic lipase immunoreactivity concentrations but there was no evidence of clinical pancreatitis. Clinical Significance: It remains unclear whether the five of 10 dogs with elevated canine pancreatic lipase immunoreactivity during prednisone treatment had subclinical pancreatitis or whether the abnormal results were a consequence of prednisolone administration.John Wiley & SonsJournal Articleapplication/pdfhttp://hdl.handle.net/2115/70667https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/70667/1/JSAP_58%286%29_342-347_for_HUSCAP.pdf0022-4510Journal of small animal practice5863423472017-06enginfo:pmid/28247954info:doi/10.1111/jsap.12652This is the peer reviewed version of the following article: H. Ohta, T. Morita, N. Yokoyama, T. Osuga, N. Sasaki, K. Morishita, K. Nakamura, M. Takiguchi, Serial measurement of pancreatic lipase immunoreactivity concentration in dogs with immune-mediated disease treated with prednisolone, Journal of Small Animal Practice, Vol. 58, Issue 6, June 2017, which has been published in final form at https://doi.org/10.1111/jsap.12652. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.author