2024-03-28T12:54:32Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/720462022-11-17T02:08:08Zhdl_2115_20043hdl_2115_137Novel Ultrasonographic Scoring System of Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell TransplantationNishida, MutsumiKahata, KaoruHayase, EikoShigematsu, AkioSato, MegumiKudo, YusukeOmotehara, SatomiIwai, TakahitoSugita, JunichiShibuya, HitoshiShimizu, ChikaraTeshima, TakanoriSinusoidal obstruction syndromeHepatic veno-occlusive diseaseUltrasonographyColor DopplerHematopoietic stem cell transplantation490Sinusoidal obstruction syndrome (SOS)/hepatic veno-occlusive disease (VOD) is a well-documented complication after hematopoietic stem cell transplantation (HSCT). Transabdominal ultrasonography (US) enables the visualization of blood flow abnormalities and is therefore useful for the diagnosis of SOS/VOD. We herein prospectively evaluated accuracy of a novel US diagnostic scoring system of SOS/VOD based on US findings. We carried out US in 106 patients on day 14 and when SOS/VOD was suspected after allogeneic HSCT. Among 106 patients, 10 patients (9.4%) were diagnosed as SOS/VOD by Baltimore or Seattle criteria. According to uni-variate analysis of 17 US findings (US-17 screening), we established a novel scoring system (HokUS-10) consisting of 10 parameters, such as gallbladder wall thickening, ascites, and blood flow signal in the paraumbilical vein. The sensitivity and specificity were 100% and 95.8%, respectively. Diagnostic performance of the HokUS-10 was significantly better than US-17 screening. In 4 of 10 patients US detection of SOS/VOD preceded to clinical diagnosis. The HokUS-10 scoring system is useful in the diagnosis of SOS/VOD; however, our results should be validated in other cohorts.ElsevierJournal Articleapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documenthttp://hdl.handle.net/2115/72046https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/72046/2/1-s2.0-S1083879118302970-main.pdfhttps://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/72046/1/1-s2.0-S1083879118302970-mmc1.docx1083-8791Biology of blood and marrow transplantation249189619002018-09enginfo:pmid/29803752info:doi/10.1016/j.bbmt.2018.05.025http://creativecommons.org/licenses/by-nc-nd/4.0/publisher