2024-03-29T15:08:29Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/728302022-11-17T02:08:08Zhdl_2115_20059hdl_2115_151Direct Synthesis of Lactams from Keto Acids, Nitriles, and H-2 by Heterogeneous Pt CatalystsSiddiki, S. M. A. H.Touchy, Abeda S.Bhosale, AshviniToyao, TakashiMahara, YujiOhyama, JunyaSatsuma, AtsushiShimizu, Ken-ichiaminationhydrogenationketo acidsnitrilesplatinum431We report herein the first general catalytic system for the direct synthesis of N-substituted gamma- and delta-lactams by reductive amination/cyclization of keto acids (including levulinic acid) with nitriles and H-2 under mild conditions (7bar H-2, 110 degrees C, solvent free). The most effective catalyst, Pt and MoOx co-loaded TiO2 (Pt-MoOx/TiO2), shows a wide substrate scope, high turnover number (TON), and good reusability.Wiley-BlackwellJournal Articleapplication/pdfhttp://hdl.handle.net/2115/72830https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/72830/1/Manuscript.pdf1867-3880ChemCatChem1047897952018-02-21enginfo:doi/10.1002/cctc.201701355This is the peer reviewed version of the following article: S. M. A. H. Siddiki, Abeda S. Touchy, Ashvini Bhosale, Takashi Toyao, Yuji Mahara, Junya Ohyama, Atsushi Satsuma, Kenāichi Shimizu. Direct Synthesis of Lactams from Keto Acids, Nitriles, and H2 by Heterogeneous Pt Catalysts. ChemCatChem Volume 10, Issue 4, Febrary 21, 2018, which has been published in final form at https://doi.org/10.1002/cctc.201701355. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.author