2024-03-29T10:59:43Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/729752022-11-17T02:08:08Zhdl_2115_20040hdl_2115_121Predictive factors for hyperglycaemic progression in patients with schizophrenia or bipolar disorderKusumi, IchiroArai, YukiOkubo, RyoHonda, MinoruMatsuda, YasuhiroMatsuda, YukihikoTochigi, AkihikoTakekita, YoshiteruYamanaka, HiroyoshiUemura, KeiichiIto, KoichiTsuchiya, KiyoshiYamada, JunYoshimura, BuntaMitsui, NobuyukiMatsubara, SigehiroSegawa, TakayukiNishi, NobuyukiSugawara, YasufumiKako, YukiShinkawa, IkutaShinohara, KaoruKonishi, AkikoIga, JunichiHashimoto, NaokiInomata, ShinsakuTsukamoto, NorikoIto, HirotoIto, Yoichi M.Sato, NorihiroSchizophreniabipolar disorderdiabetesmonitoring490Background: Patients with schizophrenia or bipolar disorder have a high risk of developing type 2 diabetes. Aims: To identify predictive factors for hyperglycaemic progression in individuals with schizophrenia or bipolar disorder and to determine whether hyperglycaemic progression rates differ among antipsychotics in regular clinical practice. Method: We recruited 1166 patients who initially had normal or prediabetic glucose levels for a nationwide, multisite, l-year prospective cohort study to determine predictive factors for hyperglycaemic progression. We also examined whether hyperglycaemic progression varied among patients receiving monotherapy with the six most frequently used antipsychotics. Results: High baseline serum triglycerides and coexisting hypertension significantly predicted hyperglycaemic progression. The six most frequently used antipsychotics did not significantly differ in their associated hyperglycaemic progression rates over the 1-year observation period. Conclusions: Clinicians should carefully evaluate baseline serum triglycerides and coexisting hypertension and perform strict longitudinal monitoring irrespective of the antipsychotic used.Cambridge University PressJournal Articleapplication/pdfhttp://hdl.handle.net/2115/72975https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/72975/1/predictive_factors_for_hyperglycaemic_progression_in_patients_with_schizophrenia_or_bipolar_disorder.pdf2056-4724BJPsych Open464544602018-11enginfo:doi/10.1192/bjo.2018.56© The Royal College of Psychiatrists 2018publisher