2024-03-28T15:57:53Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/765062022-11-17T02:08:08Zhdl_2115_20040hdl_2115_121Blonanserin suppresses impulsive action in ratsNishitani, NaoyaSasamori, HitomiOhmura, YuYoshida, TakayukiYoshioka, MitsuhiroImpulsive behavior1-PPAntipsychotics490High impulsivity will increase the risk of criminal behavior, drug abuse, and suicide. We chose two drugs by following a strategy recently we proposed for identifying potential anti-impulsivity drugs, and examined the effects on impulsive action in rats by using a 3-choice serial reaction time task. We showed that the administration of blonanserin, an atypical antipsychotic, reduced impulsive actions in a U-shaped manner. 1-(2-Pyriidinyl)-piperazine, an active metabolite of buspirone or tandospirone, also slightly reduced impulsive actions, though it impaired motor functions. These results affirm the validity of our strategy, but require its refinement for developing anti-impulsivity drugs. (C) 2019 The Authors. Production and hosting by Elsevier B.V.Japanese Pharmacological SocietyJournal Articlehttp://hdl.handle.net/2115/765061347-8613Journal of pharmacological sciences14131271302019-11enginfo:doi/10.1016/j.jphs.2019.09.013none