2024-03-29T00:05:44Zhttps://eprints.lib.hokudai.ac.jp/dspace-oai/requestoai:eprints.lib.hokudai.ac.jp:2115/822322022-11-17T02:08:08Zhdl_2115_20040hdl_2115_121Baseline elevated serum angiopoietin-2 predicts long-term non-regression of liver fibrosis after direct-acting antiviral therapy for hepatitis CKawagishi, NaokiSuda, GokiKimura, MegumiMaehara, OsamuYamada, RenTokuchi, YoshimasaKubo, AkinoriKitagataya, TakashiShigesawa, TakuSuzuki, KazuharuOhara, MasatsuguNakai, MasatoSho, TakuyaNatsuizaka, MitsuteruMorikawa, KenichiOgawa, KojiKudo, YusukeNishida, MutsumiSakamoto, Naoya490We previously revealed that Angiopoietin-2 (Ang2) predicts non-regression of liver fibrosis based on liver stiffness measurement (LSM) at 24 weeks after anti-hepatitis C virus (HCV) treatment. In this study, we extended the observational period to 96 weeks to investigate the factors associated with non-regression after treatment with direct-acting-antivirals (DAAs). Patients treated with DAAs who underwent transient elastography at baseline and 24 and 96 weeks after DAA therapy were included. Baseline and post-treatment serum Ang2 levels were measured. Liver fibrosis stages were defined based on LSM. Multivariate regression was used to evaluate factors associated with non-regression of liver fibrosis between various time points. In total, 110 patients were included. Of these, 11% showed non-regression of LSM-based fibrosis stage at 96 weeks after DAA therapy. In multivariate analysis, advanced liver fibrosis stage and high baseline Ang2 levels were significantly associated with non-regression at 96 weeks. In patients with advanced liver fibrosis (F3/4), baseline Ang2 levels were associated with non-regression of liver fibrosis stage. Between SVR24 and SVR96, post-treatment Ang2 levels and controlled attenuation parameter values at SVR24 were significantly associated with non-regression of liver fibrosis stage in patients with F3/4. Thus, serum Ang2 levels are an important target for monitoring and therapy.Nature ResearchJournal Articlehttp://hdl.handle.net/2115/822322045-2322Scientific reports11192072021-04-28enginfo:doi/10.1038/s41598-021-88632-7none