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Structural components of the synaptonemal complex, SYCP1 and SYCP3, in the medaka fish Oryzias latipes

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Title: Structural components of the synaptonemal complex, SYCP1 and SYCP3, in the medaka fish Oryzias latipes
Authors: Iwai, Toshiharu Browse this author
Yoshii, Atsushi Browse this author
Yokota, Takehiro Browse this author
Sakai, Chiharu Browse this author
Hori, Hiroshi Browse this author
Kanamori, Akira Browse this author
Yamashita, Masakane Browse this author
Keywords: Protein expression
Synaptonemal complex
Homologous chromosomes
Issue Date: 1-Aug-2006
Publisher: Elsevier Inc.
Journal Title: Experimental Cell Research
Volume: 312
Issue: 13
Start Page: 2528
End Page: 2537
Publisher DOI: 10.1016/j.yexcr.2006.04.015
PMID: 16764855
Abstract: The synaptonemal complex (SC) is a meiosis-specific structure essential for synapsis of homologous chromosomes. For the first time in any non-mammalian vertebrates, we have isolated cDNA clones encoding two structural components of the SC, SYCP1 and SYCP3, in the medaka, and investigated their protein expression during gametogenesis. As in the case of mammals, medaka SYCP1 and SYCP3 are expressed solely in meiotically dividing cells. In the diplotene stage, SYCP1 is diminished at desynaptic regions of chromosomes and completely lost on the chromosomes at later stages. SYCP3 is localized along the arm and centromeric regions of chromosomes at metaphase I, and its existence on the whole chromosomes persists up to anaphase I, a situation different from that reported in the mouse, in which SYCP3 is confined to the centromeric regions but lost on the arm regions at metaphase I. Thus, the expression patterns of SC components are different in mammals and fish despite the resemblance in morphological structure of the SC, suggesting divergence in the function of the SC in regulation of meiosis-specific chromosomal behavior. Since the antibody against medaka SYCP3 is cross-reactive to other fishes, it should be generally useful for a meiosis-specific marker in fish germ cells.
Type: article (author version)
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 山下 正兼

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