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Reversed actrocytic GLT-1 during ischemia is crucial to excitotoxic death of neurons, but contributes to the survival of astrocytes themselves.

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タイトル: Reversed actrocytic GLT-1 during ischemia is crucial to excitotoxic death of neurons, but contributes to the survival of astrocytes themselves.
著者: Kosugi, Tatsuro 著作を一覧する
Kawahara, Koichi 著作を一覧する
キーワード: Ischemia
Reversed GLT-1
Astrocyte damage
Na+/Ca2+ exchanger
Excitotoxic neuronal death
発行日: 2006年 7月
出版者: Springer Netherlands
誌名: Neurochemical Research
巻: 31
号: 7
開始ページ: 933
終了ページ: 943
出版社 DOI: 10.1007/s11064-006-9099-6
抄録: During ischemia, the operation of astrocytic/neuronal glutamate transporters is reversed and glutamate and Na+ are co-transported to the extracellular space. This study aims to investigate whether this reversed operation of glutamate transporters has any functional meanings for astrocytes themselves. Oxygen/glucose deprivation (OGD) of neuron/astrocyte co-cultures resulted in the massive death of neurons, and the cell death was significantly reduced by treatment with either AP5 or DHK. In cultured astrocytes with little GLT-1 expression, OGD produced Na+ overload, resulting in the reversal of astrocytic Na+/Ca2+-exchanger (NCX). The reversed NCX then caused Ca2+ overload leading to the damage of astrocytes. In contrast, the OGD-induced Na+ overload and astrocytic damage were significantly attenuated in PACAP-treated astrocytes with increased GLT-1 expression, and the attenuation was antagonized by treatment with DHK. These results suggested that the OGD-induced reversal of GLT-1 contributed to the survival of astrocytes themselves by releasing Na+ with glutamate via reversed GLT-1.
Rights: The original publication is available at www.springerlink.com
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/14610
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 河原 剛一

 

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