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Structure analysis of PH1161 protein, a transcriptional activator TenA homologue from the hyperthermophilic archaeon Pyrococcus horikoshii

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タイトル: Structure analysis of PH1161 protein, a transcriptional activator TenA homologue from the hyperthermophilic archaeon Pyrococcus horikoshii
著者: Itou, Hiroshi 著作を一覧する
Yao, Min 著作を一覧する
Watanabe, Nobuhisa 著作を一覧する
Tanaka, Isao 著作を一覧する
キーワード: haem oxygenase-1
PH1161 protein
TenA protein
transcriptional activator
発行日: 2004年 6月
出版者: International Union of Crystallography
誌名: Acta Crystallographica Section D Biological Crystallography
巻: 60
号: Pt 6
開始ページ: 1094
終了ページ: 1100
出版社 DOI: 10.1107/S0907444904008522
抄録: The crystal structure of the Bacillus subtilis TenA-homologue protein PH1161 from the hyperthermophilic archaebacterium Pyrococcus horikoshii was determined. TenA is known to belong to a new family of activators that stimulate the production of extracellular proteases in B. subtilis. A sequence-similarity search revealed that TenA-homologue proteins are widespread in bacteria and archaea, suggesting that this family of proteins plays an essential role in these organisms. In the present study, the first three-dimensional structure of a member of the TenA family of proteins was determined, unexpectedly revealing that the protein has a fold identical to that of haem oxygenase-1. Analysis has also shown that the protein has a unique ligand-binding pocket. Electron density of a bound ligand molecule was observed in this pocket. These results provide a valuable insight into the functional understanding of the TenA family of proteins.
Relation (URI): http://journals.iucr.org/
資料タイプ: article
URI: http://hdl.handle.net/2115/14918
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 田中 勲

 

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