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Hokkaido University Collection of Scholarly and Academic Papers >
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Structure analysis of PH1161 protein, a transcriptional activator TenA homologue from the hyperthermophilic archaeon Pyrococcus horikoshii
| Title: | Structure analysis of PH1161 protein, a transcriptional activator TenA homologue from the hyperthermophilic archaeon Pyrococcus horikoshii |
| Authors: | Itou, Hiroshi Browse this author | | Yao, Min Browse this author →KAKEN DB | | Watanabe, Nobuhisa Browse this author | | Tanaka, Isao Browse this author →KAKEN DB |
| Keywords: | haem oxygenase-1 | | PH1161 protein | | TenA protein | | transcriptional activator |
| Issue Date: | Jun-2004 |
| Publisher: | International Union of Crystallography |
| Journal Title: | Acta Crystallographica Section D Biological Crystallography |
| Volume: | 60 |
| Issue: | Pt 6 |
| Start Page: | 1094 |
| End Page: | 1100 |
| Publisher DOI: | 10.1107/S0907444904008522 |
| PMID: | 15159569 |
| Abstract: | The crystal structure of the Bacillus subtilis TenA-homologue protein PH1161 from the hyperthermophilic archaebacterium Pyrococcus horikoshii was determined. TenA is known to belong to a new family of activators that stimulate the production of extracellular proteases in B. subtilis. A sequence-similarity search revealed that TenA-homologue proteins are widespread in bacteria and archaea, suggesting that this family of proteins plays an essential role in these organisms. In the present study, the first three-dimensional structure of a member of the TenA family of proteins was determined, unexpectedly revealing that the protein has a fold identical to that of haem oxygenase-1. Analysis has also shown that the protein has a unique ligand-binding pocket. Electron density of a bound ligand molecule was observed in this pocket. These results provide a valuable insight into the functional understanding of the TenA family of proteins. |
| Relation: | http://journals.iucr.org/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/14918 |
| Appears in Collections: | 生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 田中 勲
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