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The cell membrane-shielding function of eicosapentaenoic acid for Escherichia coli against exogenously added hydrogen peroxide.

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Title: The cell membrane-shielding function of eicosapentaenoic acid for Escherichia coli against exogenously added hydrogen peroxide.
Authors: Nishida, Takanori Browse this author
Orikasa, Yoshitake Browse this author
Watanabe, Kazuo Browse this author
Okuyama, Hidetoshi Browse this author →KAKEN DB
Keywords: Antioxidative stress
Catalase-deficient E. coli
EPA
pfa genes
Issue Date: 11-Dec-2006
Publisher: Elsevier B.V.
Journal Title: FEBS Letters
Volume: 580
Issue: 28-29
Start Page: 6690
End Page: 6694
Publisher DOI: 10.1016/j.febslet.2006.11.030
PMID: 17126330
Abstract: The colony-forming ability of catalase-deficient Escherichia coli mutant genetically modified to produce eicosapentaenoic acid (EPA) showed less decrease than in a control strain producing no EPA, when treated with 0.3 mM hydrogen peroxide (H2O2) under non-growth conditions. H2O2-induced protein carbonylation was enhanced in cells lacking EPA. The amount of fatty acids was decreased more significantly for cells lacking EPA than for those producing EPA. Much lower intracellular concentrations of H2O2 were detected for cells with EPA than those lacking EPA. These results suggest that cellular EPA can directly protect cells against oxidative damage by shielding the entry of exogenously added H2O2.
Relation: http://www.sciencedirect.com/science/journal/00145793
Type: article (author version)
URI: http://hdl.handle.net/2115/17173
Appears in Collections:環境科学院・地球環境科学研究院 (Graduate School of Environmental Science / Faculty of Environmental Earth Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 奥山 英登志

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