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Latency of vestibular responses of pursuit neurons in the caudal frontal eye fields to whole body rotation.

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タイトル: Latency of vestibular responses of pursuit neurons in the caudal frontal eye fields to whole body rotation.
著者: Akao, Teppei 著作を一覧する
Saito, Hiroshi 著作を一覧する
Fukushima, Junko 著作を一覧する
Kurkin, Sergei 著作を一覧する
Fukushima, Kikuro 著作を一覧する
キーワード: Smooth pursuit
Vestibular system
Frontal eye fields
発行日: 2007年 3月
出版者: Springer
誌名: Experimental Brain Research
巻: 177
号: 3
開始ページ: 400
終了ページ: 410
出版社 DOI: 10.1007/s00221-006-0682-5
抄録: The smooth pursuit system and the vestibular system interact to keep the retinal target image on the fovea by matching the eye velocity in space to target velocity during head and/or whole body movement. The caudal part of the frontal eye fields (FEF) in the fundus of the arcuate sulcus contains pursuit-related neurons and the majority of them respond to vestibular stimulation induced by whole body movement. To understand the role of FEF pursuit neurons in the interaction of vestibular and pursuit signals, we examined the latency and time course of discharge modulation to horizontal whole body rotation during different vestibular task conditions in head-stabilized monkeys. Pursuit neurons with horizontal preferred directions were selected, and they were classified either as gaze-velocity neurons or eye/head-velocity neurons based on the previous criteria (Fukushima et al. in: J Neurophysiol 83:563–587, 2000). Responses of these neurons to whole body step-rotation at 20°/s were examined during cancellation of the vestibulo-ocular reflex (VOR), VOR ×1, and during chair steps in complete darkness without a target (VORd). The majority of pursuit neurons tested (∼70%) responded during VORd with latencies <80 ms. These initial responses were basically similar in the three vestibular task conditions. The shortest latency was 20 ms and the modal value was 24 ms. These responses were also similar between gaze-velocity neurons and eye/head-velocity neurons, indicating that the initial responses (<80 ms) were vestibular responses induced by semicircular canal inputs. During VOR cancellation and ×1, discharge of the two groups of neurons diverged at ∼90 ms following the onset of chair rotation, consistent with the latencies associated with smooth pursuit. The shortest latency to the onset of target motion during smooth pursuit was 80 ms and the modal value was 95 ms. The time course of discharge rate difference of the two groups of neurons between VOR cancellation and ×1 was predicted by the discharge modulation associated with smooth pursuit. These results provide further support for the involvement of the caudal FEF in integration of vestibular inputs and pursuit signals.
Rights: The original publication is available at
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 福島 菊郎


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